Abstract: Objective To observe the relationship between prognosis of acute chemical poisoning and acid-base balance disorder among victims. Methods Totally 105 cases of acute chemical poisoning during 1990-2009 were studied retrospectively. The relationship between some indexes such as pH value,PaO₂,PaCO₂,multiple acid-base balance disorders and prognosis such as death,organ damage and APACHE Ⅱ score was evaluated. Results All dead cases showed the abnormality of pH value,PaO₂,or multiple acid-base balance. The cases with abnormality of these indexes had more serious multiple organs damage and their APACHE Ⅱ score showed significant increment. The cases with severer carbon dioxide retention (PaCO₂>6.0 kPa)had more serious multiple organs damage. Conclusion Acute chemical poisoning may cause abnormality of pH, hypoxemia and multiple acid-base balance disorders,which results in severe consequences by affecting prognosis. However,it could provide reference for the early treatment.