邓丽丹, 汤海燕, 邓立华, 林大枫, 张艳芳, 黄先青. 肝功能损伤对职业性三氯乙烯药疹样皮炎治愈率影响的Cox回归分析[J]. 职业卫生与应急救援, 2017, 35(5): 401-404, 430. DOI: 10.16369/j.oher.issn.1007-1326.2017.05.001
引用本文: 邓丽丹, 汤海燕, 邓立华, 林大枫, 张艳芳, 黄先青. 肝功能损伤对职业性三氯乙烯药疹样皮炎治愈率影响的Cox回归分析[J]. 职业卫生与应急救援, 2017, 35(5): 401-404, 430. DOI: 10.16369/j.oher.issn.1007-1326.2017.05.001
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DENG Lidan, TANG Haiyan, DENG Lihua, LIN Dafeng, ZHANG Yanfang, HUANG Xianqing. Liver function damage and curability of occupational medicamentosa-like dermatitis induced by trichloroethylene: Cox regression analysis[J]. Occupational Health and Emergency Rescue, 2017, 35(5): 401-404, 430. DOI: 10.16369/j.oher.issn.1007-1326.2017.05.001
Citation: DENG Lidan, TANG Haiyan, DENG Lihua, LIN Dafeng, ZHANG Yanfang, HUANG Xianqing. Liver function damage and curability of occupational medicamentosa-like dermatitis induced by trichloroethylene: Cox regression analysis[J]. Occupational Health and Emergency Rescue, 2017, 35(5): 401-404, 430. DOI: 10.16369/j.oher.issn.1007-1326.2017.05.001
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肝功能损伤对职业性三氯乙烯药疹样皮炎治愈率影响的Cox回归分析

Liver function damage and curability of occupational medicamentosa-like dermatitis induced by trichloroethylene: Cox regression analysis

    摘要
  • 摘要:
    目的 探索肝功能损伤程度对职业性三氯乙烯药疹样皮炎(occupational medicamentosa-like dermatitis induced by trichloroethylene, OMDT)治愈率的可能影响。
    方法 收集2012年1月-2016年6月入院接受诊疗的所有30名OMDT病例的病程和结局资料, 用Cox回归模型分析病例住院期间检测到的血清总蛋白最低值(TPL)、白蛋白最低值(ALBL)、总胆红素最高值(TBILM)、直接胆红素最高值(DBILM)、丙氨酸氨基转移酶活性最高值(ALTM)、天门冬氨酸氨基转移酶活性最高值(ASTM)、谷氨酰转肽酶活性最高值(GGTM)、碱性磷酸酶活性最高值(ALPM)对OMDT治愈率的影响。
    结果 30名OMDT病例病程中位数为108 d, 截尾值占30.0%, 总体治愈率为70.0%。所研究肝功能损伤程度指标间存在共线性。通过主成分分析, 将前三个主成分代入Cox回归模型后发现, 主要反映TPL、ALBL、TBILM、DBILM变异的主成分1是影响OMDT治愈率最重要的因素(RR=0.62, P < 0.05)。Cox回归模型表达式显示, TPL和ALBL越高, TBILM、DBILM、ALTM、ASTM、GGTM、ALPM越低, 病例治愈率越高。
    结论 肝功能损伤程度对OMDT的治愈率有影响, 积极保护肝脏功能有助于提高病例的治愈率。

     

    Abstract:
    Objective  To explore the potential effects of the liver function damage on the curability of occupational medicamentosa-like dermatitis induced by trichloroethylene (OMDT).
    methods  The data of clinical courses and outcomes of the disease were collected from all 30 OMDT hospitalized patients from January 2012 to June 2016. The Cox regression was used to analyze the influence of minimums of serum total protein (TPL) and albumin (ALBL), and maximums of total bilirubin (TBILM), direct bilirubin (DBILM), alanine aminotransferase (ALTM), aspartate aminotransferase (ASTM), glutamyltranspeptidase (GGTM), and alkaline phosphatase (ALPM) on the curability of OMDT.
    Results  The median of courses of disease for these 30 OMDT patients was 108 days, the censored outcome was 30.0%, and the cure rate was 70.0%. There was collinearity among various liver function damage indices and the principal component analysis was used to analysis these indices. After the first three principal components were included in the Cox regression the analysis showed that the first principal component reflecting the variations of TPL, ALBL, TBILM and DBILM significantly affected the curability of OMDT (RR=0.62, P < 0.05). The model expression obtained from the Cox regression showed that the curability of OMDT increased while TPL or ALBLincreased and TBILM, DBILM, ALTM, ASTM, GGTM or ALPMdecreased.
    Conclusion  Liver function damage could affect the curability of OMDT, therefore actively protecting the liver function may help to improve the curability of the patients.

     

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