张伊莉, 郑诗凯, 傅尧, 朱海源, 邓雯婷, 林静茹, 罗兆环, 曾婉云, 刘薇薇, 杨志前, 王致. 中西医结合对慢性苯中毒患者免疫功能及生活质量影响的随机对照研究J. 职业卫生与应急救援, 2026, 44(2): 153-158. DOI: 10.16369/j.oher.issn.1007-1326.2026.250424
引用本文: 张伊莉, 郑诗凯, 傅尧, 朱海源, 邓雯婷, 林静茹, 罗兆环, 曾婉云, 刘薇薇, 杨志前, 王致. 中西医结合对慢性苯中毒患者免疫功能及生活质量影响的随机对照研究J. 职业卫生与应急救援, 2026, 44(2): 153-158. DOI: 10.16369/j.oher.issn.1007-1326.2026.250424
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ZHANG Yili, ZHENG Shikai, FU Yao, ZHU Haiyuan, DENG Wenting, LIN Jingru, LUO Zhaohuan, ZENG Wanyun, LIU Weiwei, YANG Zhiqian, WANG Zhi. A randomized controlled trial of integrated traditional Chinese medicine and Western medicine on immune function and quality of life in patients with chronic benzene poisoningJ. Occupational Health and Emergency Rescue, 2026, 44(2): 153-158. DOI: 10.16369/j.oher.issn.1007-1326.2026.250424
Citation: ZHANG Yili, ZHENG Shikai, FU Yao, ZHU Haiyuan, DENG Wenting, LIN Jingru, LUO Zhaohuan, ZENG Wanyun, LIU Weiwei, YANG Zhiqian, WANG Zhi. A randomized controlled trial of integrated traditional Chinese medicine and Western medicine on immune function and quality of life in patients with chronic benzene poisoningJ. Occupational Health and Emergency Rescue, 2026, 44(2): 153-158. DOI: 10.16369/j.oher.issn.1007-1326.2026.250424
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中西医结合对慢性苯中毒患者免疫功能及生活质量影响的随机对照研究

A randomized controlled trial of integrated traditional Chinese medicine and Western medicine on immune function and quality of life in patients with chronic benzene poisoning

    摘要
  • 摘要:
    目的 探讨中医药在慢性苯中毒治疗中的积极作用。
    方法 以2023年广州市第十二人民医院收治的49例慢性苯中毒脾肾阳虚患者为研究对象，将其随机分为中西医联合治疗组（A组，25例）和单纯西医治疗组（B组，24例），通过病例资料、《健康调查简表》（SF-36）问卷调查方法比较两组患者的中医证候评分、免疫指标、骨髓功能检查结果及生活质量评分。
    结果 治疗前，49例患者均为轻中度中毒，无累及骨髓的重度中毒，但白细胞及中性粒细胞计数均偏低。IgE的中位数为414.2 IU/mL，IL-6的中位数为97.5 pg/mL，IL-8的中位数为2 213.7 pg/mL；治疗后，两组患者的IgE水平均大幅降低（P < 0.05）。49例患者治疗后中医证候平均总积分低于治疗前（P < 0.05），且A组在面色白光白、神疲乏力等证候改善方面优于B组（P < 0.05）；治疗后，A组在《健康调查简表》上的所有维度得分均有提高（P < 0.001），而B组仅在部分维度上的得分高于治疗前（P < 0.05）。
    结论 中西医联合治疗在改善慢性苯中毒脾肾阳虚型患者的中医证候、提升其生活质量方面可能优于单纯西药治疗，而单纯西医治疗对患者生活质量的改善较为有限。

     

    Abstract:
    Objective To investigate the potential benefits of traditional Chinese medicine (TCM) in the diagnosis and treatment of chronic benzene poisoning.
    Methods A total of 49 patients with chronic benzene poisoning characterized by spleen-kidney yang deficiency, admitted to the Guangzhou Twelfth People's Hospital in 2023, were enrolled and randomly assigned to Group A (combined therapy with TCM-Western medicine, n = 25) or Group B (therapy with Western medicine alone, n = 24). The two groups were compared in terms of TCM syndrome scores, immune indicators, and bone marrow function abstracted from clinical records and quality of life scores surveyed by medical records and the Short Form-36 Health Survey (SF-36).
    Results Before treatment, all 49 patients had mild to moderate benzene poisoning without severe bone marrow involvement, although both leukocyte and neutrophil counts were lower than reference values. The median levels of IgE, IL-6, and IL-8 were 414.2 IU/mL, 97.5 pg/mL, and 2 213.7 pg/mL, respectively. After treatment, IgE levels decreased significantly in both groups (P < 0.05). The mean of the total TCM syndrome score of all patients was significantly lower after treatment (P < 0.05), with Group A showing greater improvements in symptoms such as pale complexion and fatigue compared with Group B(P < 0.05). After treatment, Group A demonstrated significant improvements across all SF-36 dimensions (P < 0.001), whereas Group B showed improvements in only some dimensions (P < 0.05).
    Conclusions Combination therapy of TCM and Western medicine may be superior to Western medicine alone in improving TCM syndrome manifestations and enhancing quality of life in patients with chronic benzene poisoning characterized by spleen-kidney yang deficiency, while Western medicine alone showed limited improvement in overall quality of life.

     

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