Abstract: Objective To establish a method for sampling and determining cisplatin, an antitumor drug, in workplace air, providing technical support for assessing occupational exposure to cisplatin among healthcare workers. Methods Cisplatin in simulated workplace air was collected using microporous membrane filters. Samples were pretreated by nitric acid digestion and analyzed using inductively coupled plasma mass spectrometry (ICP-MS). Results The average sampling efficiency of airborne cisplatin, using microporous membrane filters, ranged from 95.30% to 100.00%. Analysis of platinum standard solutions showed a good linear relationship between the ratio of platinum to internal standard response and platinum concentration within the range of 0 to 100.00 μg/L, with a correlation coefficient of 0.999 3. The lower limit of quantification was 0.14 μg/L. The minimum quantifiable concentrations of cisplatin in air were 2.9 × 10^-5 mg/m³ for a 75 L air sample and 4.5 × 10^-6 mg/m³ for a 480 L air sample. The average digestion efficiency of cisplatin was 95.20% to 102.49%, with intra-batch relative standard deviation (RSD) of 0.40% to 0.87% and inter-batch RSD of 1.18% to 2.40%. The average spiked recovery ranged from 100.91% to 105.20%. Samples remained stable for at least 14 days at room temperature. Conclusions This method demonstrated high sampling efficiency, good precision, high accuracy, and sample stability, making it suitable for sampling and determining cisplatin in workplace air.