陈欢, 尹扬光, 刘永生. PM2.5对心力衰竭发生、发展和预后的影响及机制J. 职业卫生与应急救援, 2022, 40(5): 620-624. DOI: 10.16369/j.oher.issn.1007-1326.2022.05.024
引用本文: 陈欢, 尹扬光, 刘永生. PM2.5对心力衰竭发生、发展和预后的影响及机制J. 职业卫生与应急救援, 2022, 40(5): 620-624. DOI: 10.16369/j.oher.issn.1007-1326.2022.05.024
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CHEN Huan, YING Yangguang, LIU Yongsheng. The effect and mechanism of fine particulate matter on the occurrence, progress and prognosis of heart failureJ. Occupational Health and Emergency Rescue, 2022, 40(5): 620-624. DOI: 10.16369/j.oher.issn.1007-1326.2022.05.024
Citation: CHEN Huan, YING Yangguang, LIU Yongsheng. The effect and mechanism of fine particulate matter on the occurrence, progress and prognosis of heart failureJ. Occupational Health and Emergency Rescue, 2022, 40(5): 620-624. DOI: 10.16369/j.oher.issn.1007-1326.2022.05.024
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PM2.5对心力衰竭发生、发展和预后的影响及机制

The effect and mechanism of fine particulate matter on the occurrence, progress and prognosis of heart failure

    摘要
  • 摘要: 细颗粒物（particulate matter 2.5，PM2.5）对心血管系统有显著不利影响，可增加心力衰竭（heart failure，HF）患病率、住院率和病死率。PM2.5对HF的影响机制包括：诱导心肌细胞肥大、坏死、凋亡使心肌细胞数量减少，导致心肌纤维化异常激活使心室重构，影响心肌细胞内钙稳态及能量代谢使心脏收缩和舒张功能受损。减少PM2.5污染对HF防治有重要意义。

     

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