张伊莉, 刘薇薇, 刘移民. 不同途径汞中毒对机体影响的分析研究[J]. 职业卫生与应急救援, 2015, 33(4): 234-237. DOI: 10.16369/j.oher.issn.1007-1326.2015.04.002
引用本文: 张伊莉, 刘薇薇, 刘移民. 不同途径汞中毒对机体影响的分析研究[J]. 职业卫生与应急救援, 2015, 33(4): 234-237. DOI: 10.16369/j.oher.issn.1007-1326.2015.04.002
ZHANG Yili, LIU Weiwei, LIU Yimin. Study of clinical characteristics of mercury poisonings via different exposure routes[J]. Occupational Health and Emergency Rescue, 2015, 33(4): 234-237. DOI: 10.16369/j.oher.issn.1007-1326.2015.04.002
Citation: ZHANG Yili, LIU Weiwei, LIU Yimin. Study of clinical characteristics of mercury poisonings via different exposure routes[J]. Occupational Health and Emergency Rescue, 2015, 33(4): 234-237. DOI: 10.16369/j.oher.issn.1007-1326.2015.04.002

不同途径汞中毒对机体影响的分析研究

Study of clinical characteristics of mercury poisonings via different exposure routes

  • 摘要: 目的 研究不同接触途径所致汞中毒的临床特点。 方法 将33例患者按汞进入体内途径的不同分为3组,即呼吸道吸入中毒组、消化道摄入中毒组和皮肤吸收中毒组,分析其临床特点。 结果 3种不同接触途径所致汞中毒的临床表现各有特点,呼吸道吸入中毒组呼吸系统症状较突出,试排尿汞升高明显。皮肤吸收中毒组以亚急性中毒为主,无明显症状,多为肾病等,发病后检查发现尿汞升高;消化道摄入中毒者为急性起病,可伴有胃肠道症状,治疗后尿汞值最低。治疗前呼吸道吸入中毒组的平均尿汞值分别为消化道摄入中毒组、皮肤吸收中毒组的18.5倍和9.2倍;呼吸道吸入中毒组的试排平均尿汞水平高达5 838.2 μg/gCr。呼吸道吸入中毒组患者平均治疗3.91个疗程,其中58.3%患者超过5个疗程;消化道摄入中毒组患者平均治疗仅1.56个疗程,其中55.56%病例仅需治疗一个疗程;皮肤吸收中毒组患者平均治疗2.25个疗程,其中50%的患者超过5个疗程。3组患者治疗所用疗程比较,差异有统计学意义(F=8.98,P<0.05)。 结论 3种不同接触途径所致汞中毒临床表现不一,应强化汞中毒诊疗规范,以达到早期有效治疗,减少后遗症,降低死亡率。

     

    Abstract: Objective To study the clinical characteristics of mercury poisoning via different exposure routes. Methods According to exposure pathway,33 patients with mercury poisoning were mainly divided into three groups,namely the inhalational, the digestive and the dermal groups and their clinical features were analyzed. Results The patients due to inhalation exposure had more prominent respiratory symptom and higher urinary level of mercury. Some patients had difficulty in breathing. The urinary level of mercury of the inhalational group was 18.5 and 9.5 times higher than the digestive and the dermal group respectively before the treatment. The urinary mercury of the inhalational group was as high as 5 838.2 μg/gCr. They received averagely 3.91 courses of treatment and 58.3% cases were treated for more than 5 courses. The patients due to digestive exposure had acute onset with typical gastrointestinal symptoms. They were treated averagely for 1.56 courses while 55.56% were cases treated for only 1 course. The patients due to dermal exposure had mostly kidney damage and then diagnosed as sub-acute poisoning. They were treated averagely for 2.25 course and 50% cases were treated for more than 5 courses.The courses among those three groups had Statistical difference (F=8.98,P<0.05). Conclusion The patients of mercury poisoning due to different exposure ways had varied clinical manifestation. The diagnosis and treatment should be specified to achieve early diagnosis and treatment,and reduce sequela and mortality.

     

/

返回文章
返回