易娟, 刘征宇, 李添娣, 张健杰, 刘健, 林怡然, 李双凤. 三氯乙烯药疹样皮炎患者细胞因子水平分析[J]. 职业卫生与应急救援, 2015, 33(2): 89-91. DOI: 10.16369/j.oher.issn.1007-1326.2015.02.005
引用本文: 易娟, 刘征宇, 李添娣, 张健杰, 刘健, 林怡然, 李双凤. 三氯乙烯药疹样皮炎患者细胞因子水平分析[J]. 职业卫生与应急救援, 2015, 33(2): 89-91. DOI: 10.16369/j.oher.issn.1007-1326.2015.02.005
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YI Juan, LIU Zheng-yu, LI Tian-di, ZHANG Jian-jie, LIU Jian, LIN Yi-ran, LI Shuang-feng. Serum cytokines levels in patients with trichloroethylene induced medicamentosa-like dermatitis[J]. Occupational Health and Emergency Rescue, 2015, 33(2): 89-91. DOI: 10.16369/j.oher.issn.1007-1326.2015.02.005
Citation: YI Juan, LIU Zheng-yu, LI Tian-di, ZHANG Jian-jie, LIU Jian, LIN Yi-ran, LI Shuang-feng. Serum cytokines levels in patients with trichloroethylene induced medicamentosa-like dermatitis[J]. Occupational Health and Emergency Rescue, 2015, 33(2): 89-91. DOI: 10.16369/j.oher.issn.1007-1326.2015.02.005
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三氯乙烯药疹样皮炎患者细胞因子水平分析

Serum cytokines levels in patients with trichloroethylene induced medicamentosa-like dermatitis

    摘要
  • 摘要: 目的 探讨三氯乙烯(TCE)药疹样皮炎患者血清γ干扰素(IFN-γ)、肿瘤坏死因子(TNF-α)、白细胞介素4(IL-4)和白细胞介素10(IL-10)细胞因子水平的变化。 方法 采用酶联免疫吸附法(ELISA)测定52例患者和52例正常人血清中IFN-γ、TNF-α、IL-4、IL-10水平,并比较其水平差异,同时分析患者各细胞因子水平的相关性。 结果 病例组血清中IFN-γ、TNF-α、IL-4、IL-10水平中位值(范围)分别为20.59(12.64~198.00)、53.46(26.14~306.60)、28.05(12.83~256.36)、12.77(4.48~245.05) ng/L,对照组分别为13.62(6.03~28.18)、19.97(11.72~43.81)、12.34(10.39~22.39)、5.63(2.77~18.77) ng/L,以上4种结果在两组间比较,差异均有统计学意义(z=-5.649、-5.891、-5.416、-5.264,P<0.01);病例组血清中IFN-γ、TNF-α、IL-4、IL-10四种细胞因子水平均相互呈正相关(P<0.01)。 结论 IFN-γ、TNF-α、IL-4、IL-10在TCE药疹样皮炎发生过程中具有重要意义,可用于预测工人发病倾向以及发病趋势。

     

    Abstract: Objective To observe the level changes of serum cytokines including interferon (IFN-γ),tumor necrosis factor (TNF-α),interleukin 4(IL-4) and interleukin 10(IL-10) in patients with trichloroethylene induced medicamentosa-like dermatitis (DMLT),to help understand the toxicity mechanism. Methods ELISA was used to detect serum IFN-γ,TNF-α,IL-4 and IL-10 concentrations in 52 DMLT patients and 52 controls. Results The levels of Serum IFN-γ,TNF-α,IL-4 and IL-10 were 20.59(12.64-198.00),53.46(26.14-306.60),28.05(12.83-256.36),12.77(4.48-245.05) ng/L in the DMLT patients,while were 13.62(6.03-28.18),19.97(11.72-43.81),12.34(10.39-22.39),5.63(2.77-18.77) ng/L in the control group,respectively.The serum levels of IFN-γ,TNF-α,IL-4 and IL-10 in the case group were higher than those in the control group (z=-5.649,-5.891,-5.416,-5.264,respectively,P<0.01).There were positive correlations among these cytokines levels. Conclusion IFN-γ,TNF-α,IL-4 and IL-10 maybe play important roles in the pathogenesis of DMLT.

     

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