杨玉新, 孙晓静, 赵海涛, 张程鹏, 曹泽仁, 崔守明, 张光辉. 铅作业工人血铅水平和肝功能状况及其影响因素[J]. 职业卫生与应急救援, 2019, 37(2): 113-117, 125. DOI: 10.16369/j.oher.issn.1007-1326.2019.02.003
引用本文: 杨玉新, 孙晓静, 赵海涛, 张程鹏, 曹泽仁, 崔守明, 张光辉. 铅作业工人血铅水平和肝功能状况及其影响因素[J]. 职业卫生与应急救援, 2019, 37(2): 113-117, 125. DOI: 10.16369/j.oher.issn.1007-1326.2019.02.003
YANG Yuxin, SUN Xiaojing, ZHAO Haitao, ZHANG Chengpeng, CAO Zeren, CUI Shouming, ZHANG Guanghui. Blood lead level and liver function status of occupationally lead-exposed workers and their influence factors[J]. Occupational Health and Emergency Rescue, 2019, 37(2): 113-117, 125. DOI: 10.16369/j.oher.issn.1007-1326.2019.02.003
Citation: YANG Yuxin, SUN Xiaojing, ZHAO Haitao, ZHANG Chengpeng, CAO Zeren, CUI Shouming, ZHANG Guanghui. Blood lead level and liver function status of occupationally lead-exposed workers and their influence factors[J]. Occupational Health and Emergency Rescue, 2019, 37(2): 113-117, 125. DOI: 10.16369/j.oher.issn.1007-1326.2019.02.003

铅作业工人血铅水平和肝功能状况及其影响因素

Blood lead level and liver function status of occupationally lead-exposed workers and their influence factors

  • 摘要:
    目的 了解铅作业工人血铅水平及肝功能状况,分析其影响因素,为保护工人健康提供依据。
    方法 选择某铅酸蓄电池公司1 179名体检工人为研究对象。接触组为一线接触铅的801名工人,对照组为该企业行政、后勤类等378名非铅接触者。采用问卷调查和健康体检相结合的方法,收集工人基础信息并进行数据分析。
    结果 铅作业工人血铅水平范围为89~463 μg/L,其MP25P75)为152.2(65.4,356.7)μg/L,血铅超标率(血铅值≥400 μg/L)为10.2%。铅接触组血铅异常率高于对照组,差异有统计学意义(P < 0.01)。logistic回归分析发现接触组血铅升高的风险是对照组的7.321倍(P < 0.01);血铅水平> 200~300 μg/L组、> 300~400 μg/L组及> 400 μg/L组发生肝功能异常的风险为 < 100 μg/L组的1.775倍、2.659倍和3.114倍(P均 < 0.05),10~13年工龄组及5~ < 10年工龄组发生肝功能异常的风险是 < 5年组的1.454倍和1.122倍(P < 0.05);血铅水平> 200~300 μg/L组、> 300~400 μg/L组及> 400 μg/L组发生肝脏B超异常的风险为 < 100 μg/L组的1.650倍、2.219倍和2.658倍(P均 < 0.05),铅接触组B超异常风险是对照组的2.235倍(P < 0.05)。
    结论 职业铅接触引起工人血铅水平升高,血铅是肝功能和肝脏B超异常的独立危险因素,故应加强工人健康监护。

     

    Abstract:
    Objective To understand blood lead level(BLL)and liver function status of occupationally lead-exposed workers and to analyze their influence factors so as to provide orientation for protecting workers' health.
    Methods Totally 1 179 workers in a lead-acid battery company were studied, including 801 workers exposed to lead and 378 non-exposed workers(administrative and logistic workers). They were surveyed with questionnaire and occupational health examination.
    Results The levels of blood lead ranged from 89 to 463 μg/L and the M(P25, P75) was 152.2(65.4, 356.7)μg/L among these workers, and 10.2% workers had higher BLL than biological exposure limit (400 μg/L). The abnormal rate of blood lead in exposure group was significant higher than that in non-exposure group with the risk of 7.321-fold (P < 0.01). Logistic regression analysis showed that the risk of abnormal liver function among workers with LLB of 200-300 μg/L, 301-400 μg/L and more than 400 μg/L was 1.775, 2.659 and 3.114 (P < 0.05), respectively, compared with workers with LLB of lower than 100 μg/L. The risks of abnormal liver function among workers with employed time of 10-13 years and 5-9 years was 1.454 and 1.122 (P < 0.05), respectively, compared with workers with employed time of less than 5 years. The risk of abnormal ultrasonic B examination among workers with LLB of 200-300 μg/L, 301-400 μg/L and more than 400 μg/L was 1.650, 2.219 and 2.658 (P < 0.05), respectively, compared with workers with LLB of lower than 100 μg/L. The risk of abnormal B-mode ultrasonography among lead-exposed workers was 2.235 times higher than non-exposed workers (P < 0.05).
    Conclusion Occupational lead exposure induced the blood lead level increase, and BLL was an independent risk factor for abnormality of liver function and ultrasonic B examination. Health surveillance should be strengthened in routine occupational health work.

     

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