杨秋月, 王海椒, 曹香府, 刘丽华, 邹晓雪, 伍家琪, 毕磊. 煤工尘肺患者血清TNF-α水平及意义[J]. 职业卫生与应急救援, 2020, 38(3): 258-261. DOI: 10.16369/j.oher.issn.1007-1326.2020.03.011
引用本文: 杨秋月, 王海椒, 曹香府, 刘丽华, 邹晓雪, 伍家琪, 毕磊. 煤工尘肺患者血清TNF-α水平及意义[J]. 职业卫生与应急救援, 2020, 38(3): 258-261. DOI: 10.16369/j.oher.issn.1007-1326.2020.03.011
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YANG Qiuyue, WANG Haijiao, CAO Xiangfu, LIU Lihua, ZOU Xiaoxue, WU Jiaqi, BI Lei. Serum TNF- α level of patients with coal workers' pneumoconiosis and its clinical significance[J]. Occupational Health and Emergency Rescue, 2020, 38(3): 258-261. DOI: 10.16369/j.oher.issn.1007-1326.2020.03.011
Citation: YANG Qiuyue, WANG Haijiao, CAO Xiangfu, LIU Lihua, ZOU Xiaoxue, WU Jiaqi, BI Lei. Serum TNF- α level of patients with coal workers' pneumoconiosis and its clinical significance[J]. Occupational Health and Emergency Rescue, 2020, 38(3): 258-261. DOI: 10.16369/j.oher.issn.1007-1326.2020.03.011
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煤工尘肺患者血清TNF-α水平及意义

Serum TNF- α level of patients with coal workers' pneumoconiosis and its clinical significance

    摘要
  • 摘要:
    目的 通过检测煤工尘肺患者血清中肿瘤坏死因子-α（tumor necrosis factor alpha，TNF-α）水平，为了解其在煤工尘肺发展过程中的变化动态提供实验依据。
    方法 利用便利抽样方法，选取北京某医院117例煤工尘肺患者，调查相关信息，采用酶联免疫法检测患者外周血TNF-α水平。
    结果 不同工龄、不同期别和不同吸烟状况下煤工尘肺患者之间的血清TNF-α水平差异均无统计学意义（P > 0.05）；但工龄、尘肺病诊断年限与TNF-α水平均存在一定程度的相关关系（rs = 0.603、0.186，P < 0.05）；随着诊断年限的增长，TNF-α水平呈现升高的趋势，≤10年、11 ~ 20年和> 20年患者TNF-α浓度分别为（0.99 ±0.39）pg/mL、（1.20 ±0.47）pg/mL和（1.21 ±0.44）pg/mL，差异有统计学意义（P < 0.05）。
    结论 血清中TNF-α水平可能与煤工尘肺的发展有一定关系，其具体机制有待进一步研究探讨。

     

    Abstract:
    Objective To study the serum tumor necrosis factor-α (TNF-α) level of patients with coal workers' pneumoconiosis(CWP) and its association with CWP progress.
    Methods Totally 117 cases with CWP were studied. The demographic information, the occupational exposure history, and the diagnosis history were surveyed with questionnaire or abstracted from medical history records and their serum TNF-α was detected by enzyme-linked immunosorbent assay.
    Results There was no difference of serum TNF-α level among patients with different exposure time, the pneumoconiosis stage and smoking status(P > 0. 05), but there was a correlation between serum TNF-α level and the exposure time and diagnosed time (rs = 0.603, 0.186, P < 0.05). The patients diagnosed with CWP for less than 10, 10 - 20 and more than 20 years had serum level of (0.99 ±0.39), (1.20 ±0.47) and (1.21 ±0.44) pg/mL, respectively, and the level had an increasing trend with diagnosis time(F = 3.350, P < 0.05).
    Conclusion The level of TNF-α in serum may be related to the progress of CWP, however the mechanisms needs to be further studied.

     

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