Abstract: Objective The objectives of this study are to investigate the effective treatment methods of hydrofluoric acid burn wounds, and provide a reference for the clinical treatment of hydrofluoric acid burns. Methods Hydrofluoric acid burn cases were collected by searching the Tongfang full-text database, Wanfang digital periodical database, VIP science and technology periodical database and China Biological and Medical Journal Full-text database between August of 2002 and July of 2012. The data were extracted after screening. The statistical data were analyzed using SPSS 16.0 software. Results A total of 54 articles (1 566 cases) were included in the study. Binary classification logistic regression analysis showed that immediate washing and application of glucocorticoid hormones played positive roles in the treatment of hydrofluoric acid burn. The gender male was a protective factor for the complete cure of hydrofluoric acid burn. Admission to hospitals 3 days after burn was a risk factor. Conclusion For patients suffering from burn, it should be paid more attention to immediate flush and early emergency treatments, timely application of weak bases and rapidly complement large doses of calcium in the early stages. Avoiding the occurrence of hypocalcemia, arrhythmic and other complications was a key during the treatments, and applications of glucocorticoid had positive effects for the treatment of hydrofluoric acid burns.