Serum cytokines levels in patients with trichloroethylene induced medicamentosa-like dermatitis

Objective To observe the level changes of serum cytokines including interferon (IFN-γ),tumor necrosis factor (TNF-α),interleukin 4(IL-4) and interleukin 10(IL-10) in patients with trichloroethylene induced medicamentosa-like dermatitis (DMLT),to help understand the toxicity mechanism. Methods ELISA was used to detect serum IFN-γ,TNF-α,IL-4 and IL-10 concentrations in 52 DMLT patients and 52 controls. Results The levels of Serum IFN-γ,TNF-α,IL-4 and IL-10 were 20.59(12.64-198.00),53.46(26.14-306.60),28.05(12.83-256.36),12.77(4.48-245.05) ng/L in the DMLT patients,while were 13.62(6.03-28.18),19.97(11.72-43.81),12.34(10.39-22.39),5.63(2.77-18.77) ng/L in the control group,respectively.The serum levels of IFN-γ,TNF-α,IL-4 and IL-10 in the case group were higher than those in the control group (z=-5.649,-5.891,-5.416,-5.264,respectively,P<0.01).There were positive correlations among these cytokines levels. Conclusion IFN-γ,TNF-α,IL-4 and IL-10 maybe play important roles in the pathogenesis of DMLT.