Effects of different doses of Xuebijing injection on prognosis of patients with severe acute pancreatitis

  Objective  To investigate the efficacy of different doses of Xuebijing injection in the treatment of patients with severe acute pancreatitis, specifically the improvement of inflammatory indexes and organ function.

  Methods  Patients with severe acute pancreatitis were divided into three groups: routine treatment (n = 70), low-dose Xuebijing treatment (n = 61), and high-dose Xuebijing treatment (n = 53). The patients were treated according to the guidelines for the treatment of acute pancreatitis, which included fluid resuscitation, etiology removal, and organ function maintenance; additionally, the patients in the Xuebijing treatment groups received Xuebijing (100 mL in low dose and 200 mL in high dose) in intravenous drip per day for ≥ 7 days. The inflammatory indexes, routine blood biochemical indexes, and organ function index scores, the proportion and timing of receiving invasive respiratory support treatment, and prognostic indexes including pancreatic necrosis score, laparotomy, hospitalization days, and mortality were compared among these groups.

  Results  After one week of treatment, the white blood cells, scores of C-reactive protein and APACHE Ⅱ of patients in the high-dose group were significantly improved compared with those in the conventional treatment group (P < 0.05), while there was no significant difference between patients in the low-dose group and the conventional treatment group (P > 0.05). The time of mechanical ventilation (9.59 ±7.43) d in the high-dose Xuebijing treatment group was shorter than that in the low dose Xuebijing treatment group (15.83 ±15.18) d and the conventional treatment group (20.96 ±23.29) d (P < 0.05), while the difference was not statistically significant between the low dose treatment group and the conventional treatment group. Compared with the conventional treatment group, the proportion of laparotomy, hospitalization days in the high-dose group were significantly reduced (P < 0.05), but there was no significant difference in pancreatic necrosis score and mortality among these three groups (P > 0.05), and there was no significant difference in these four indicators between the low-dose Xuebijing treatment group and the conventional treatment group (P > 0.05).

  Conclusions  Conventional therapy combined with high-dose Xuebijing therapy can effectively improve the inflammatory indexes and organ function of patients with severe acute pancreatitis, improve the prognosis, and shorten the hospitalization time.